Leptin Protein, Rat,specification,price,image-Bio-Equip in China

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Product Specification

Species	Rat
Synonyms	Leptin, rRtLeptin, Obesity protein (OB), LEP
Accession	P50596
Amino Acid Sequence	Val22-Cys167
Expression System	E.coli
Molecular Weight	15kDa
Purity	>95% by SDS-PAGE
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	No Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	20mM Tris, 80mM NaCl, 5%trehalose, pH8.0
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	1、Wodarski K. et al. (2009) Leptin as a modulator of osteogenesis. Ortop Traumatol Rehabil. 11(1): 1-6. 2、Tezapsidis N. et al. (2009) Leptin: a novel therapeutic strategy for Alzheimer's disease. J Alzheimers Dis. 16(4): 731-740. 3、Cai C. et al. (2009) Leptin in non-autoimmune inflammation. Inflamm Allergy Drug Targets. 8(4): 285-291. 4、Fernndez-Riejos P. et al. (2010) Role of leptin in the activation of immune cells. Mediators Inflamm. 2010: 568343. 5、Kelesidis T. et al. (2010) Narrative review: the role of leptin in human physiology: emerging clinical applications. Ann Intern Med. 152(2): 93-100.

Background

Leptin (LEP) is a 16kDa peptide hormone produced mainly by white adipocyte tissue. Leptin is involved in maintaining gastric epithelial cell integrity and gastroprotection. In rats, systemic leptin is effective in attenuating both ethanol- and aspirin-induced damage to the gastric mucosa. This is correlated with an increase of leptin production by the stomach during experimentally-induced gastric damage in rats and during H pylori infection in humans. This gastric cytoprotective effect of leptin involves an increase in blood flow, local production of nitric oxide and prostaglandin E2, and vagus nerve-dependent mechanisms. One of the important functions of leptin is its role in the regulation of inflammatory processes. There is indeed a large body of evidence that leptin-mediated signal pathways play an active role in innate and adaptive immunity through alteration of various target genes transcription.