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IGF-I Protein, Mouse
IGF-I Protein, Mouse
Origin of place Singapore
Model UA040099-10μg
Supplier ANT BIO PTE.LTD.
Price 99.2
Hits 2
Updated 8/27/2025
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Product Specification


SpeciesMouse
AntigenIGF-1
SynonymsIGF-I Protein, IGF1A Protein, IGFI Protein
AccessionP05017
Amino Acid SequenceGly49-Ala118
Expression SystemE.coli
Molecular Weight

8-9kDa (Non-Reducing)

Purity

＞95% by SDS-PAGE

Endotoxin<0.1EU/μg
ConjugationUnconjugated
TagNo Tag
Physical AppearanceLyophilized Powder
Storage Buffer50mM NaAc, pH6.0.
ReconstitutionReconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1.Bartlett WP,Li XS, Williams M. 1992. Brain Res Mol Brain Res, 12: 285-91.


Background

Insulin-like growth factor I (IGF-I) belongs to the family of insulin-like growth factors that are structurally homologous to proinsulin. Mature IGFs are generated by proteolytic processing of inactive precursor protein containing N-terminal and C-terminal propeptide regions. IGF-1 is produced primarily by the liver as an endocrine hormone as well as in target tissues in a paracrine/autocrine fashion. The production of IGF-1 is stimulated by growth hormone (GH) and can be retarded by undernutrition, growth hormone insensitivity, lack of growth hormone receptors, or failures of the downstream signaling pathway post GH receptor including SHP2 and STAT5B. IGF1 binds IGF-1R, IGF-2R, and the insulin receptor and plays a key role in cell cycle progression, cell proliferation and tumor progression.

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