OSMR/IL-31RB His Tag Protein, Mouse,specification,price,image-Bio-Equip in China

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Product Specification

Species	Mouse
Antigen	OSMR/IL-31RB
Synonyms	IL-31R subunit beta, IL-31R-beta, OSMRB
Accession	O70458
Amino Acid Sequence	Glu24-Met737, with C-terminal 10*His EVLEEPLPLTPEIHKVSFQLKLQEVNLEWTVPALTHEELNMIFQIEISRLNISNTIWVENYSTTVKREEAVRWNWTSDIPLECVKHFIRIRALVDDTKSLPQSSWGNWSSWKEVNAKVSVEPDKSLIFPKDKVLEEGSNVTICLMYGQNVYNVSCKLQDEPIHGEQLDSHVSLLKLNNVVFLSDTGTNINCQATKGPKRIFGTVLFVSKVLEEPKNVSCETRDFKTLDCSWEPGVDTTLTWRKQRFQNYTLCESFSKRCEVSNYRNSYTWQITEGSQEMYNFTLTAENQLRKRSVNINFNLTHRVHPKAPQDVTLKIIGATKANMTWKVHSHGNNYTLLCQVKLQYGEVIHEHNVSVHMSANYLFSDLDPDTKYKAFVRCASANHFWKWSDWTQKEFSTPETAPSQALDVWRQVWSENGRRIVTLFWKPLLKSQANGKIISYNIVVENEAKPTESEHYCVWAPALSTNLSLDLQPYKIRITTNNSMGASPESLMVLSNDSGHEEVKEKTIKGIKDAFNISWEPVSGDTMGYVVDWCAHSQDQRCDLQWKNLGPNTTSTTITSDDFKPGVRYNFRIFERSVEHKARLVEKQRGYTQELAPLVNPKVEIPYSTPNSFVLRWPDYDSDFQAGFIKGYLVYVKSKEMQCNQPWERTLLPDNSVLCKYDINGSETKTLTVENLQPESLYEFFVTPYTSAGPGPNETFTKVTTPDARSHMGGGSGGGSHHHHHHHHHH
Expression System	HEK293
Molecular Weight	110-135kDa (Reducing)
Purity	>95% by SDS-PAGE
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	His Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, pH7.4
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	1.Qing Guo, Ge‐fei Guan, Jing‐yuan Cao, Cun‐yi Zou, Chen Zhu, Wen Cheng. Overexpression of oncostatin M receptor regulates local immune response in glioblastoma. OR IGINAL RESEARCH ARTICLE.

Background

Oncostatin M receptor (OSMR), also named as IL‐31R‐β, is a cytokine receptor gene of IL‐6 family and transduces oncostatin M (OSM) and IL‐31 signaling. A recent study shows that OSMR expression is elevated in GBM, especially mesenchymal subtype. OSM/OSMR signaling has been shown to play an important role in driving the glioma cells towards mesenchymal type, and correlated with poor survival. Moreover, OSMR is a direct transcriptional target gene of STAT3 and forms a physical complex with epidermal growth factor receptor vIII (EGFRvIII), a truncated EGFR in which exons 2−7 are deleted. OSMR also promotes the proliferation of human brain tumor stem cells (BTSCs) and the depletion of OSMR impaired EGFRvIII‐STAT3 signaling. Additionally, OSMR may be a key factor and related to JAK/STAT signaling in mediating the effect of endogenous bornavirus‐like nucleoprotein elements on the proliferation and apoptosis of oligodendroglia cells.