GPNMB Fc Chimera Protein, Human,specification,price,image-Bio-Equip in China

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Product Specification

Species	Human
Antigen	GPNMB
Synonyms	HGFIN, NMB, Osteoactivin
Accession	Q14956
Amino Acid Sequence	Lys23-Asn498, with C-terminal Human IgG Fc KRFHDVLGNERPSAYMREHNQLNGWSSDENDWNEKLYPVWKRGDMRWKNSWKGGRVQAVLTSDSPALVGSNITFAVNLIFPRCQKEDANGNIVYEKNCRNEAGLSADPYVYNWTAWSEDSDGENGTGQSHHNVFPDGKPFPHHPGWRRWNFIYVFHTLGQYFQKLGRCSVRVSVNTANVTLGPQLMEVTVYRRHGRAYVPIAQVKDVYVVTDQIPVFVTMFQKNDRNSSDETFLKDLPIMFDVLIHDPSHFLNYSTINYKWSFGDNTGLFVSTNHTVNHTYVLNGTFSLNLTVKAAAPGPCPPPPPPPRPSKPTPSLATTLKSYDSNTPGPAGDNPLELSRIPDENCQINRYGHFQATITIVEGILEVNIIQMTDVLMPVPWPESSLIDFVVTCQGSIPTEVCTIISDPTCEITQNTVCSPVDVDEMCLLTVRRTFNGSGTYCVNLTLGDDTSLALTSTLISVPDRDPASPLRMANIEGRMDPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
Expression System	HEK293
Molecular Weight	95-110kDa
Purity	>95% by SDS-PAGE
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	Human Fc Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, pH7.4
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	1.Hassan Ashktorab, Hamed Rahi. GPNMB methylation: a new marker of potentially carcinogenic colon lesions. BMC Cancer 2018 Nov 6;18(1):1068.

Background

GlycoProtein Non-metastatic Melanoma B (GPNMB)was discovered in 1995, through a study on two melanoma cell lines with low and high metastatic abilities. The authors determined and characterized GPNMB cDNA that was highly expressed in the low metastatic cell line. GPNMB is located on the short arm of chromosome 7 (7p15) and known as neurokinin-1 type, hematopoietic growth factor inducible (HGFIN). It is a type I transmembrane protein that has three unique domains: an extracellular, a transmembrane, and a cytoplasmic one. The extracellular domain consists of two regions with different properties, an integrin-binding motif (RGD) and a polycystic kidney disease (PKD) domain. The cytoplasmic tail has two functionally different parts including a dileucine-based sorting signal and a half immunoreceptor tyrosine-based activation motif(hemITAM).