Cadherin-1/CDH1 Fc Chimera Protein, Human,specification,price,image-Bio-Equip in China

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Product Specification

Species	Human
Antigen	Cadherin-1/CDH1
Synonyms	CAM 120/80, Epithelial cadherin (E-cadherin), Uvomorulin
Accession	P12830
Amino Acid Sequence	Asp155-Ala709, with C-terminal Human IgG1 Fc DWVIPPISCPENEKGPFPKNLVQIKSNKDKEGKVFYSITGQGADTPPVGVFIIERETGWLKVTEPLDRERIATYTLFSHAVSSNGNAVEDPMEILITVTDQNDNKPEFTQEVFKGSVMEGALPGTSVMEVTATDADDDVNTYNAAIAYTILSQDPELPDKNMFTINRNTGVISVVTTGLDRESFPTYTLVVQAADLQGEGLSTTATAVITVTDTNDNPPIFNPTTYKGQVPENEANVVITTLKVTDADAPNTPAWEAVYTILNDDGGQFVVTTNPVNNDGILKTAKGLDFEAKQQYILHVAVTNVVPFEVSLTTSTATVTVDVLDVNEAPIFVPPEKRVEVSEDFGVGQEITSYTAQEPDTFMEQKITYRIWRDTANWLEINPDTGAISTRAELDREDFEHVKNSTYTALIIATDNGSPVATGTGTLLLILSDVNDNAPIPEPRTIFFCERNPKPQVINIIDADLPPNTSPFTAELTHGASANWTIQYNDPTQESIILKPKMALEVGDYKINLKLMDNQNKDQVTTLEVSVCDCEGAAGVCRKAQPVEAGLQIPAIEGRMDPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK
Expression System	HEK293
Molecular Weight	95-102kDa
Purity	＞95% by SDS-PAGE
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	Human Fc
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, pH7.4
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	1. Nelson WJ. Regulation of cell-cell adhesion by the cadherin-catenin complex. Biochem Soc Trans. 2008 Apr;36(Pt 2):149-55. 2. Gumbiner BM. Regulation of cadherin adhesive activity. J Cell Biol. 2000 Feb 7;148(3):399-404.

Background

CDH1 (also known as epithelial cadherin (E-cadherin), a member of the cadherin- catenin complex, is an example in which pathogenic variants can lead to CLP and/or gastric cancer. The human CDH1 gene consists of 16 exons that span 100 kb. Classical cadherins are a family of single-span transmembrane domain glycoproteins that primarily mediate calcium-dependent cell–cell adhesion, which are differentially expressed throughout the body. Cadherins are single-membrane-spanning proteins with a divergent extracellular domain of five repeats and a conserved cytoplasmic domain. Much experimental evidence suggests that the CDH1 is a tumor suppressor and alterations in its expression are linked with multiple tumor types and its clinicopathological features. Loss of CDH1 is used for the diagnosis and prognosis of epithelial cancers.