Ubiquitin-specific peptidase 47 (USP47) is a member of the USP subfamily of DUBs. Similaring to other USPs, USP47 regulates cellular activities by removing ubiquitin conjugates from diverse substrates and, thereby, altering their stabilities, localizations, or activities. Specifically, USP47 deubiquitinates and stabilizes MAPK, DNA polymerase β (Polβ), E-cadherin, β catenin, SNAIL, YAP, β-Trcp, and katanin-p60. Hence, USP47 is involved in cell proliferation, cell survival, DNA damage repair, NLRP3 inflammasome activation, and epithelial-mesenchymal transition. USP47 plays an important role in cancers such as gastric cancer, medulloblastoma, and colorectal cancer.