Chemokines are a class of cytokines that can cause cells to undergo chemotactic movement, and their main role in the body is in chemotactic cell migration. They are widely expressed in various tissues and cells of the body, and their receptors are mainly expressed in white blood cells, mediating the directional migration of white blood cells to play a biological role. CCL3, one of the components of the chemokinep CC ligand family was also termed as MIP (macrophage inflammatory protein). It can be expressed on the surface of macrophages, lymphocytes, epithelial cells, and other cells. It mediates the secretion of cytokines by immune cells and promotes the aggregation and migration of a variety of cells. C-C motif chemokine receptor 1 (CCR1) and CCR5 are the receptors of CCL3.C-C motif chemokine ligand 3 (CCL3) belongs to inflammatory cell chemokine. CCL3 or macrophage inflammatory protein-1α (MIP-1α), an important chemokine implicated in both immune surveillance and tolerance, has emerged as a prognostic biomarker in both solid and hematological malignancies.