MCP-1/CCL2 Protein, Human,specification,price,image-Bio-Equip in China

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Product Specification

Species	Human
Synonyms	C-C motif chemokine 2; HC11; Monocyte chemoattractant protein 1; Monocyte chemotactic and activating factor (MCAF); Monocyte chemotactic protein 1 (MCP-1); Monocyte secretory protein JE; Small-inducible cytokine A2;
Accession	P13500
Amino Acid Sequence	Gln24-Thr99
Expression System	E.coli
Molecular Weight	8.7 kDa (Reducing)
Purity	＞95% by SDS-PAGE
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	No Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	20mM Tris, 500mM NaCl, pH8.0
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	1. Cytokine Growth Factor Rev. 2010 Feb;21(1):41-8. Epub 2009 Dec 14.

Background

MCP-1, also known as CCL2, is a chemokine belonging to the C-C chemokine family. It plays a crucial role in various physiological processes such as inflammation, immune regulation, and cell migration. MCP-1/CCL2 primarily functions by binding to the C-C chemokine receptor CCR2, thereby guiding monocytes and other inflammatory cells to migrate to sites of inflammation, contributing to the inflammatory response and immune regulation.

Overexpression of MCP-1/CCL2 is closely associated with the pathogenesis and progression of various diseases, including inflammatory diseases, autoimmune disorders, cancer, and metabolic disorders. As a result, MCP-1/CCL2 has emerged as a potential therapeutic target, and researchers are exploring therapeutic strategies targeting MCP-1/CCL2 in the hope of impacting the treatment of related diseases.