TNFR-2/CD120b His Tag Protein, Cynomolgus,specification,price,image-Bio-Equip in China

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Product Specification

Species	Cynomolgus
Synonyms	TNFRSF1B, TBPII, TNF-R-II, TNF-R75, TNFBR, TNFR1B, TNFR80
Accession	XP_005544817.1
Amino Acid Sequence	Leu23-Asp257, with C-8*His
Expression System	HEK293
Molecular Weight	35-45kDa (Reducing)
Purity	＞95% by SDS-PAGE
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	His Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, pH7.4.
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	Jingchao Bai , Hui Li. Targeting TNFR2 in Cancer: All Roads Lead to Rome. Front Immunol. 2022 Feb 17:13:844931. eCollection 2022.

Background

TNF receptor 2 (TNFR2) has become one of the best potential immune checkpoints that might be targeted, mainly because of its vital role in tumor microenvironments (TMEs). Overexpression of TNFR2 in some tumor cells and essential function in immunosuppressive cells, especially regulatory T cells (Tregs), makes blocking TNFR2 an excellent strategy in cancer treatment; however, there is evidence showing that activating TNFR2 can also inhibit tumor progression in vivo.