Product SpecificationSpecies | Human | Synonyms | GLP-1; GLP-1-R; GLP-1R | Accession | P43220 | Concentration | 1.08 mg/ml | Amino Acid Sequence | R24-F257, E262-K437, S193C, I196F, S225A, M233C, S271A, I317C, G318I, G361C, K346A, C347F, E387D
| Expression System | Baculovirus-InsectCells | Molecular Weight | 57.3KDa | Endotoxin | <1EU/μg | Conjugation | Unconjugated | Tag | His Tag, Flag Tag | Physical Appearance | Liquid | Storage Buffer | 20 mM HEPES pH 7.5, 150 mM NaCl, 0.05% (w/v) GDN, 0.005% (w/v) CHS. | Stability & Storage |
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Background
A 7-transmembrane protein that functions as a receptor for glucagon-like peptide 1 (GLP-1) hormone, which stimulates glucose-induced insulin secretion. This receptor, which functions at the cell surface, becomes internalized in response to GLP-1 and GLP-1 analogs, and it plays an important role in the signaling cascades leading to insulin secretion. It also displays neuroprotective effects in animal models. Polymorphisms in this gene are associated with diabetes. The protein is an important drug target for the treatment of type 2 diabetes and stroke. Alternative splicing of this gene results in multiple transcript variants.
Guidelines
For complete recovery, mix well and spin before use. Product must not be store in diluted solutions. Aliquots below 10l are not advisable. Avoid repetitive freeze-thaw cycles!
bio-equip.cn
AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.
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