CXCL10 Protein, Mouse,specification,price,image-Bio-Equip in China

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Product Specification

Species	Mouse
Synonyms	Gamma-IP10, Small-inducible Cytokine B10, C7, Interferon-gamma Induced Protein CRG-2
Accession	P17515
Amino Acid Sequence	Ile22-Pro98
Expression System	E.coli
Molecular Weight	8.7 kDa
Purity	>97% by SDS-PAGE & HPLC
Endotoxin	<1EU/μg
Conjugation	Unconjugated
Tag	No Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	2 × PBS, pH 7.4.
Reconstitution	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
Stability & Storage	Use a manual defrost freezer and avoid repeated freeze-thaw cycles. - 12 months from date of receipt, -20 to -70 °C as supplied. - 1 month, 2 to 8 °C under sterile conditions after reconstitution. - 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Reference	1. Luster AD, Unkeless JC, Ravetch JV. 1985. Nature. 315:672-6. 2. Luster AD, Jhanwar SC, Chaganti RS, et al. 1987. Proc Natl Acad Sci U S A. 84:2868-71. 3. Vanguri P, Farber JM. 1990. J Biol Chem. 265:15049-57. 4. Booth V, Keizer DW, Kamphuis MB, et al. 2002. Biochemistry. 41:10418-25. 5. Dufour JH, Dziejman M, Liu MT, et al. 2002. J Immunol. 168:3195-204. 6. Angiolillo AL, Sgadari C, Taub DD, et al. 1995. J Exp Med. 182:155-62.

Background

CXCL10 also known as IP-10 is belonging to the CXC chemokine family. It is encoded by the CXCL10 gene, and in murine it is also named the CRG-2 gene. The gene was originally identified as an immediate early gene induced in response to macrophage activation. This chemokine elicits its effects by binding to the cell surface chemokine receptor CXCR3. CXCL10 has been shown to be a chemoattractant for activated T-lymphocytes and monocytes/macrophages. It also has other roles, such aspromotion of T cell adhesion to endothelial cells, and inhibition of bone marrow colony formation and angiogenesis. Murine CXCL10 shares approximately 67 % amino acid sequence identity with human CXCL10.