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Siglec-7 His Tag Protein, Human
Siglec-7 His Tag Protein, Human
Origin of place Singapore
Model UA010751-25μg
Supplier ANT BIO PTE.LTD.
Price 364
Hits 0
Updated 8/25/2025
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Product Specification


SpeciesHuman
SynonymsCDw328,AIRM-1,Adhesion inhibitory receptor molecule 1,D-siglec,QA79 membrane protein,CD328, siglec-7
AccessionQ9Y286-1
Amino Acid SequenceGln19-Leu353, with C-terminal His Tag
Expression SystemHEK293
Molecular Weight45-70kDa (Reducing)
Purity

>95% by SDS-PAGE

Endotoxin<0.1EU/μg
ConjugationUnconjugated
TagHis Tag
Physical AppearanceLyophilized Powder
Storage BufferPBS, pH7.4.
ReconstitutionReconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1.Crocker, P.R. et al. (1998) Glycobiology 8:v.

2.Crocker, P.R. and A. Varki (2001) Trends Immunol. 22:337.

3.Crocker, P.R. and A. Varki (2001) Immunology 103:137.

4.Angata, T. et al. (2002) J. Biol. Chem. 277:24466.

Background

Siglecs (sialic acid binding Ig-like lectins) are I-type (Ig-type) lectins belonging to the Ig superfamily. They are sialoadhesin/CD169/Siglec-1, CD22/Siglec-2, CD33/Siglec-3, Myelin-Associated Glycoprotein (MAG/Siglec-4a) and Siglecs 5 to 11. To date, no Siglec has been shown to recognized any cell surface ligand other than sialic acids, suggesting that interactions with glycans containing this carbohydrate are important in mediating the biological functions of Siglecs. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.  In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells.

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