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CNTF Protein, Rat
CNTF Protein, Rat
Origin of place Singapore
Model UA040187-10μg
Supplier ANT BIO PTE.LTD.
Price 192
Hits 0
Updated 8/25/2025
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Product Specification


SpeciesRat
SynonymsCiliary neurotrophic factor
AccessionP20294
Amino Acid SequenceAla2-Met200
Expression SystemE.coli
Molecular Weight22kDa (Reducing)
Purity>95% by SDS-PAGE&RP HPLC
Endotoxin<0.1EU/μg
ConjugationUnconjugated
TagNo Tag
Physical AppearanceLyophilized Powder
Storage Buffer20mM PB, 2mM TCEP, pH 7.5
ReconstitutionReconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1.Prog Retin Eye Res. 2012 Mar;31(2):136-51. Epub 2011 Dec 10.

Background

Ciliary neurotrophic factor (CNTF) is a pluripotent neurotrophic factor originally isolated from chick embryo ciliary neurons. CNTF has potent effects on the development and maintenance of the nervous system, inducing neuronal survival and differentiation by stimulating gene expression of sensory, sympathetic and motor neurons. Ciliary neurotrophic factor (CNTF) is the most extensively studied member of the cytokine family that signal through intracellular chains of the gp130/LIFRβ receptor. A large body of evidence demonstrates that CNTF promotes rod photoreceptor survival in almost all animal models. Recent studies indicate that CNTF also promotes cone photoreceptor survival and cone outer segment regeneration in the degenerating retina and improves cone function in dogs with congenital achromotopsia.

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