4-1BB Ligand/TNFSF9 His Tag Protein, Rat,specification,price,image-Bio-Equip in China

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Product Specification

Species	Rat
Synonyms	4-1BB Ligand, TNFSF9, CD137L
Accession	Q80WE6
Amino Acid Sequence	Pro106-Gly308, with N-terminal His
Expression System	HEK293
Molecular Weight	30-42kDa (Reducing)
Purity	＞95% by SDS-PAGE&HPLC
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	His Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, pH7.4.
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	1.Cancer Res.2019 Feb 15;79(4):783-794.

Background

The 4-1BB ligand (4-1BBL), also known as CD137L, is a type II transmembrane protein that is part of the TNF superfamily. 4-1BBL is the high affinity ligand of 4-1BB. Its receptor, CD137/4-1BB, is found on a variety of cells, including inflamed endothelial cells, where its expression enhances extravasation of CD137L expressing monocytes. 4-1BB Ligand is expressed by activated B cells, monocytes, macrophages, dendritic cells (DC), T cells, lymphoma and multiple myeloma cells, hematopoietic stem cells, early myeloid progenitors, neurons, and astrocytes. 4-1BBL induces the proliferation of activated peripheral blood T-cells. Also, 4-1BBL may have a role in activation-induced cell death (AICD).