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Human PRDM1/Blimp1 Protein, His tag
Human PRDM1/Blimp1 Protein, His tag
Origin of place Singapore
Model S0A0175-10μg
Supplier ANT BIO PTE.LTD.
Price 435
Hits 0
Updated 8/25/2025
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Product Specification


SpeciesHuman
SynonymsPR domain zinc finger protein 1, BLIMP-1, Beta-interferon gene positive regulatory domain I-binding factor, PR domain-containing protein 1, Positive regulatory domain I-binding factor 1 (PRDI-BF1; PRDI-binding factor 1), BLIMP1
AccessionO75626
Amino Acid Sequence

Protein sequence (O75626, Lys38-Gln223, with C-His tag) KMDMEDADMTLWTEAEFEEKCTYIVNDHPWDSGADGGTSVQAEASLPRNLLFKYATNSEEVIGVMSKEYIPKGTRFGPLIGEIYTNDTVPKNANRKYFWRIYSRGELHHFIDGFNEEKSNWMRYVNPAHSPREQNLAACQNGMNIYFYTIKPIPANQELLVWYCRDFAERLHYPYPGELTMMNLTQ

Expression SystemE.coli
Molecular WeightPredicted MW: 23.5 kDa Observed MW: 25 kDa
Purity锛?5% by SDS-PAGE
Endotoxin<1EU/渭g
ConjugationUnconjugated
Tagwith C-His tag
Physical AppearanceLiquid
Storage Buffer

Supplied as a 0.2 渭m filtered solution of 0.2M PBS, pH7.4 with 5% glycerol.

Stability & Storage

12 months from date of receipt, -20鈩?as supplied.

Background

PRDM1 (PR domain zinc finger protein 1) is a transcription factor critical for cell fate determination and terminal differentiation. It plays a pivotal role in B cell development, driving mature B cells into antibody-secreting plasma cells while repressing B cell identity genes. Beyond immunity, PRDM1 regulates differentiation in other lineages, such as T cells and epithelial cells, and acts as a tumor suppressor in multiple cancers by inhibiting cell proliferation and inducing apoptosis. Dysregulation of PRDM1 is linked to lymphoid malignancies (e.g., multiple myeloma, diffuse large B-cell lymphoma) and solid tumors.

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