Human CLEC9A Protein, hFc tag,specification,price,image-Bio-Equip in China

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Product Specification

Species	Human
Synonyms	C-type lectin domain family 9 member A, CD370
Accession	Q6UXN8
Amino Acid Sequence	Protein sequence (Q6UXN8, Lys57-Val241, with C-hFc tag) KLLQVSTIAMQQQEKLIQQERALLNFTEWKRSCALQMKYCQAFMQNSLSSAHNSSPCPNNWIQNRESCYYVSEIWSIWHTSQENCLKEGSTLLQIESKEEMDFITGSLRKIKGSYDYWVGLSQDGHSGRWLWQDGSSPSPGLLPAERSQSANQVCGYVKSNSLLSSNCSTWKYFICEKYALRSSV
Expression System	HEK293
Molecular Weight	Predicted MW: 47.3 kDa Observed MW: 60 kDa
Purity	＞95% by SDS-PAGE
Endotoxin	<0.1EU/μg
Conjugation	Unconjugated
Tag	with C-hFc tag
Physical Appearance	Lyophilized Powder
Storage Buffer	Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4.
Reconstitution	Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.
Stability & Storage	12 months from date of receipt, -20 to -70 °C as supplied. 6 months, -20 to -70 °C under sterile conditions after reconstitution. 1 week, 2 to 8 °C under sterile conditions after reconstitution. Please avoid repeated freeze-thaw cycles.

Background

C-type lectin domain family 9 member A is a protein that in humans is encoded by the CLEC9A gene. CLEC9A is a group V C-type lectin-like receptor (CTLR) that functions as an activation receptor and is expressed on myeloid lineage cells. CLEC9A ligation enhances antigen uptake and processing, leading to presentation on MHC class I and cytotoxic T cell (CTL) priming. Its recognition of filamentous actin in dead cells is important for triggering an immune response to necrotic cell debris. CLEC9A is also required for the presentation of viral proteins and the subsequent CTL-mediated killing of virus-infected cells. CLEC9A signaling triggers activation of the tyrosine kinase Syk.