Login    Join free Add to favorites    中文
Home >Products> Reagents >Other Reagents> Human LAG-3 Protein, His tag
Human LAG-3 Protein, His tag
Human LAG-3 Protein, His tag
Origin of place Singapore
Model S0A1131-25μg
Supplier ANT BIO PTE.LTD.
Price 250
Hits 0
Updated 8/25/2025
  • Product Detail
  • Company Profile

Product Specification


SpeciesHuman
SynonymsLymphocyte activation gene 3 protein, CD223, LAG3, FDC
AccessionP18627
Amino Acid Sequence

Protein sequence (P18627, Leu23-Leu450, with C-His tag) LQPGAEVPVVWAQEGAPAQLPCSPTIPLQDLSLLRRAGVTWQHQPDSGPPAAAPGHPLAPGPHPAAPSSWGPRPRRYTVLSVGPGGLRSGRLPLQPRVQLDERGRQRGDFSLWLRPARRADAGEYRAAVHLRDRALSCRLRLRLGQASMTASPPGSLRASDWVILNCSFSRPDRPASVHWFRNRGQGRVPVRESPHHHLAESFLFLPQVSPMDSGPWGCILTYRDGFNVSIMYNLTVLGLEPPTPLTVYAGAGSRVGLPCRLPAGVGTRSFLTAKWTPPGGGPDLLVTGDNGDFTLRLEDVSQAQAGTYTCHIHLQEQQLNATVTLAIITVTPKSFGSPGSLGKLLCEVTPVSGQERFVWSSLDTPSQRSFSGPWLEAQEAQLLSQPWQCQLYQGERLLGAAVYFTELSSPGAQRSGRAPGALPAGHL

Expression SystemHEK293
Molecular Weight

Predicted MW: 47.9 kDa Observed MW: 60 kDa

Purity>95% by SDS-PAGE
Endotoxin<0.1EU/μg
ConjugationUnconjugated
Tagwith C-His tag
Physical AppearanceLyophilized Powder
Storage Buffer

Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4.

ReconstitutionReconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.
Stability & Storage

12 months from date of receipt, -20 to -70 °C as supplied.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
1 week, 2 to 8 °C under sterile conditions after reconstitution.
Please avoid repeated freeze-thaw cycles.

Background

Lymphocyte-activation gene 3, also known as LAG-3, is a cell surface molecule with diverse biological effects on T cell function but overall has an immune inhibitory effect. LAG3's main ligand is MHC class II, to which it binds with higher affinity than CD4. The protein negatively regulates cellular proliferation, activation, and homeostasis of T cells, in a similar fashion to CTLA-4 and PD-1 and has been reported to play a role in Treg suppressive function. LAG3 also helps maintain CD8+ T cells in a tolerogenic state and, working with PD-1, helps maintain CD8 exhaustion during chronic viral infection. LAG3 is known to be involved in the maturation and activation of dendritic cells.

bio-equip.cn
Request Infomation

* Name:
Title:
* Tel:
Fax:
* E-mail:
Postcode:
Institution/Company:
Address:
* Country:
Request infomation:
yes no
Request Quotation:
yes no
* Message:
Validated Code:
refresh
I agree to share my inquiry to the other matching suppliers.



Copyright(C) 2006-2025 Bio-Equip    E-mail:web@bio-equip.cn   沪ICP备06040519号