Human MX1, His tag,specification,price,image-Bio-Equip in China

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Product Specification

Species	Human
Synonyms	Interferon-induced protein p78 (IFI-78K), Interferon-regulated resistance GTP-binding protein MxA, Myxoma resistance protein 1, Myxovirus resistance protein 1
Accession	P20591
Amino Acid Sequence	Protein sequence (P20591, Ala37-Glu366, with C-10*His) AENNLCSQYEEKVRPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVALPRGSGIVTRCPLVLKLKKLVNEDKWRGKVSYQDYEIEISDASEVEKEINKAQNAIAGEGMGISHELITLEISSRDVPDLTLIDLPGITRVAVGNQPADIGYKIKTLIKKYIQRQETISLVVVPSNVDIATTEALSMAQEVDPEGDRTIGILTKPDLVDKGTEDKVVDVVRNLVFHLKKGYMIVKCRGQQEIQDQLSLSEALQREKIFFENHPYFRDLLEEGKATVPCLAEKLTSELITHICKSLPLLENQIKETHQRITEELQKYGVDIPEGGGGSHHHHHHHHHH
Expression System	E.coli
Molecular Weight	Predicted MW: 38.4 kDa Observed MW: 43 kDa
Purity	＞90% by SDS-PAGE
Endotoxin	<1EU/μg
Tag	with C-10*His
Physical Appearance	Lyophilized Powder
Storage Buffer	Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4.
Reconstitution	Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation.
Stability & Storage	12 months from date of receipt, -20 to -70 °C as supplied. 6 months, -20 to -70 °C under sterile conditions after reconstitution. 1 week, 2 to 8 °C under sterile conditions after reconstitution. Please avoid repeated freeze-thaw cycles.

Background

Interferon-induced GTP-binding protein Mx1 is a protein that in humans is encoded by the MX1 gene. This cytoplasmic protein is a member of both the dynamin superfamily and the family of large GTPases. MX1 is an antiviral protein that confers resistance to RNA viruses. MX1 has GTPase activity, and GTP-bound MX1 adopts a conformation that enables interaction with viral nucleocapsids. This interaction blocks transport of viral nucleocapsids to the nucleus, which prevents transcription of the viral genome. Structural studies suggest that the antiviral activity of MX1 involves the formation of MX1 oligomeric rings around viral nucleocapsids. In mice, the interferon-inducible Mx protein is responsible for a specific antiviral state against influenza virus infection.