Product Specification| Species | Human | | Synonyms | CD158f | | Accession | Q8N109 | | Amino Acid Sequence | His22-His240, with C-terminal hIgG1 Fc and Avitag | | Expression System | HEK293 | | Molecular Weight | 65-72kDa (Reducing) | | Purity | ＞95% by SDS-PAGE | | Endotoxin | <1EU/μg | | Physical Appearance | Lyophilized Powder | | Storage Buffer | PBS, pH7.4. | | Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. | | Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
| | Reference | 1.Estefania, E. et al. (2007) J. Immunol. 178:4402.
2.Lanier, L. L. (2005) Annu. Rev. Immunol. 23:225.
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BackgroundKiller cell immunoglobulin-like receptor 2DL5(KIR2DL5), which belongs to the immunoglobulin superfamily, is an inhibitory receptor of NK cells.KIR2DL5 (CD158f) is the most recently identified inhibitory member of human killer-cell Ig-like receptors (KIRs), which enable NK cells to sense self-HLA.KIR2DL5 is encoded by two paralogous genes displaying copy number variation and allelic polymorphism-KIR2DL5A and KIR2DL5B. Functional polymorphisms in both its promoter and its coding regions are critical for understanding the KIR2DL5 role in immunity and its importance for human health.
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