Product Specification| Species | Human | | Synonyms | NOTCH2, hN2, N2ECD | | Accession | Q04721 | | Amino Acid Sequence | Leu26-Gln530, with C-terminal hIgG1 Fc | | Expression System | HEK293 | | Molecular Weight | 85-93kDa (Reducing) | | Purity | ＞95% by SDS-PAGE | | Endotoxin | <0.1EU/μg | | Conjugation | Unconjugated | | Physical Appearance | Lyophilized Powder | | Storage Buffer | PBS, pH7.4. | | Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. | | Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
| | Reference | 1.Gene ID: 4853, updated on 12-Dec-2023.
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BackgroundHuman Notch-2 is a 300 kDa type I transmembrane glycoprotein. Members of this Type 1 transmembrane protein family share structural characteristics and play a role in a variety of developmental processes by controlling cell fate decisions. As a receptor for the membrane-binding ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1), the ligands, activated by the released notch intracellular domain (NICD), form a transcription activator complex with RBPJ/RBPSUH to activate the division site enhancer gene.
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