Biotinylated ICAM-1/CD54 His&Avi Tag Protein, Human,specification,price,image-Bio-Equip in China

Product Detail
Company Profile

Product Specification

Species	Human
Synonyms	BB2, ICAM1, CD54, P3.58
Accession	P05362-1
Amino Acid Sequence	Gln28-Glu480, with C-terminal His and Avitag
Expression System	HEK293
Molecular Weight	72-90kDa (Reducing)
Purity	＞95% by SDS-PAGE
Endotoxin	<1EU/μg
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, pH7.4.
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	1. Theresa N. Ramos; Daniel C. Bullard; Scott R. Barnum:ICAM-1: Isoforms and Phenotypes, J Immunol (2014) 192 (10): 4469–4474.

Background

ICAM-1 is a cell surface glycoprotein expressed at a low basal level in immune, endothelial (EC) and epithelial cells, but is up-regulated in response to inflammatory stimulation. The function of ICAM-1 has been best studied in leukocyte transendothelial migration (TEM), where ICAM-1 regulates leukocyte rolling and adhesive interactions with the vessel wall, and guides leukocyte crossing of the endothelial layer. More recently, functional studies identified several new roles of ICAM-1 in epithelial injury-resolution responses, innate and adaptive immune responses in inflammation, and tumorigenesis.