Biotinylated B7-H4 Avi&His Tag Protein, Human,specification,price,image-Bio-Equip in China

Product Detail
Company Profile

Product Specification

Species	Human
Synonyms	B7-H4, VTCN1, B7S1, B7h.5
Accession	Q7Z7D3-1
Amino Acid Sequence	Phe29-Ala258, with C-terminal His and Avitag
Expression System	HEK293
Molecular Weight	43-60kDa (Reducing)
Purity	＞95% by SDS-PAGE
Endotoxin	<1EU/μg
Tag	Avi Tag, His Tag
Physical Appearance	Lyophilized Powder
Storage Buffer	PBS, pH7.4.
Reconstitution	Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage	· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles.
Reference	1. Yuping Sun, Yunshan Wang, Jianqiang Zhao, Ming Gu, Ricardo Giscombe, Ann Kari Lefvert a, Xiongbiao Wang: B7-H3 and B7-H4 expression in non-small-cell lung cancer, Lung Cancer Volume 53, Issue 2, August 2006, Pages 143-151.

Background

V-set domain-containing T-cell activation inhibitor 1 (VTCN1) is also known as Immune costimulatory protein B7-H4, Protein B7S1, T-cell costimulatory molecule B7x, B7H4, which belongs to the immunoglobulin superfamily and BTN/MOG family. VTCN1 contains two Ig-like V-type (immunoglobulin-like) domains. The expression of VTCN1 is up-regulated by IL6 and IL10 and is inhibited by GM-CSF and IL4 on antigen-presenting cells (APCs). VTCN1/B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. VTCN1 involved in promoting epithelial cell transformation.