The N-terminal fragment of pro-brain natriuretic peptide (N-terminal-prohormone Brain Natriuretic Peptide, NT-proBNP), whose molecular weight is 8.5kDa, belongs to the natriuretic peptide family protein, also known as type B brain natriuretic peptide, which has the functions of natriuretic, diuretic, vasodilation and so on. NT-proBNP is mainly synthesized and secreted by ventricular myocytes. Cardiac dysfunction such as high ventricular load and increased wall tension are the main conditions for stimulating NT-proBNP secretion, and the intensity of these stimulating factors is proportional to the content of NT-proBNP. Therefore, NT-proBNP can reflect the changes of ventricular function with strong specificity and high sensitivity, is a very important clinical marker of heart failure, and plays an irreplaceable role in early heart failure screening, prognosis evaluation and so on.