The perfect activator for peptide synthesis at elevated temperature.

Overview

OxymaPure® used with DIC produces peptides with increased yield and decreased epimerization when used as an alternative to HOBt1 . This safe, non-explosive auxiliary nucleophile works with carbodiimide coupling strategies to provide the best results for a peptide synthesis. Additionally, the use of DIC/Oxyma avoids side reactions associated with high levels of base (≥ 1 equiv. DIEA) using onium salt methods such as HBTU/DIEA.
 

1R. Subirós-Funosas, et al. (2009) Chem. Eur. J., 15, 9394.

 

Features

Extremely fast acylation rates

Non-explosive (compared to HOBt)

Low cost

Highly soluble in peptide synthesis solvents 

CEM Corporation is a leading global provider of solutions for critical laboratory application in analytical laboratory, chemical synthesis, biotechology, environmental testing, and food processing markets. The company was founded in 1978 and has nearly 200 patents and over 10 R&D 100 awards for its microwave-based products. CEM's headquarters is located in Matthews, NC and operates subsidiaries in the United Kingdom, France, Germany, Ireland, Italy, and Japan.