Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. HIST3H3（histone cluster 3 H3) is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from HIST3H3 lack polyA tails; instead, they contain a palindromic termination element. HIST3H3 is located separately from the other H3 genes that are in the histone gene cluster on chromosome 6p22-p21.3.

The antibody detects endogenous Histone H3 protein.

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB: 1:500-1000, IHC-p: 1:100-200.

Histone H3 Polyclonal Antibody product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

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