MBTPS2 （membrane bound transcription factor peptidase, site 2)encodes a intramembrane zinc metalloprotease, which is essential in development. This protease functions in the signal protein activation involved in sterol control of transcription and the ER stress response. Mutations in MBTPS2 have been associated with ichthyosis follicularis with atrichia and photophobia (IFAP syndrome); IFAP syndrome has been quantitatively linked to a reduction in cholesterol homeostasis and ER stress response.

S2P Polyclonal Antibody detects endogenous levels of S2P protein.

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IF: 1:200-1:1000, ELISA: 1:20000. Not yet tested in other applications.

S2P Polyclonal Antibody product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

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