MTNR1A encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin.

MEL-1A-R Polyclonal Antibody detects endogenous levels of MEL-1A-R protein.

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IF: 1:200-1:1000, ELISA: 1:5000. Not yet tested in other applications.

MEL-1A-R Polyclonal Antibody product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

Find more details at http://www.abbkine.com/product/mel-1a-r-polyclonal-antibody-abp55288.