Three phosphofructokinase isozymes exist in humans: muscle, liver and platelet. These isozymes function as subunits of the mammalian tetramer phosphofructokinase, which catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-bisphosphate. Tetramer composition varies depending on tissue type. PFKM encodes the muscle-type isozyme. Mutations in PFKM have been associated with glycogen storage disease type VII, also known as Tarui disease. Alternatively spliced transcript variants have been described

PFKM Polyclonal Antibody detects endogenous levels of PFKM protein.

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB: 1:500-1:2000, IHC-p: 1:100-1:300, ELISA: 1:10000. Not yet tested in other applications.

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