TNF receptor superfamily member 11b encoded by TNFRSF11B is a member of the TNF-receptor superfamily. TNF receptor superfamily member 11b is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. TNF receptor superfamily member 11b specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that TNF receptor superfamily member 11b and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of TNFRSF11B have been reported, but their full length nature has not been determined.

OPG Polyclonal Antibody detects endogenous levels of OPG protein.

Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB: 1:500-1:2000, IHC-p: 1:100-1:300, IF: 1:200-1:1000, ELISA: 1:10000. Not yet tested in other applications.

OPG Polyclonal Antibody product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.

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