SLFN5 (Schlafen family member 5) is a protein-coding gene that belongs to the Schlafen family, which is involved in various biological processes such as cell cycle regulation, immune response, and viral infection. SLFN5 has been identified as a regulator of cell motility and invasion in renal cell carcinoma, and its expression is associated with poor prognosis in colorectal adenocarcinoma. Additionally, SLFN5 acts as a restriction factor against herpes simplex virus type 1 (HSV-1) infection by suppressing viral transcription. It is also regulated by the androgen receptor in castration-resistant prostate cancer.