NMDAR2B protein, also known as GRIN2B or GluN2B, is a subunit of the N-methyl-D-aspartate (NMDA) receptor, which is a ligand-gated ion channel that plays a crucial role in synaptic plasticity, learning, and memory formation. It is highly expressed in the brain and is involved in long-term potentiation, an activity-dependent increase in synaptic transmission efficiency underlying certain types of memory. NMDAR2B is essential for brain development and synaptic function, with its phosphorylation at specific sites regulating receptor activity and localization. Additionally, NMDAR2B has been implicated in various neurological disorders, such as Alzheimer鈥檚 disease, epilepsy, and ischemic neuronal cell death. Recent studies also suggest its involvement in cancer progression, where it can be phosphorylated and interact with other proteins to enhance cell migration and invasion.