Phospho-TGF 尾 Receptor I (Ser165) is a phosphorylated form of the Transforming Growth Factor-beta Receptor Type I (TGFBR1), a transmembrane serine/threonine kinase that plays a crucial role in transmitting TGF-beta signals from the cell surface to the cytoplasm. This receptor forms a complex with TGF-beta type II receptors and is activated upon binding to TGF-beta ligands, leading to the phosphorylation of downstream SMAD proteins, which then regulate gene transcription involved in cell cycle control, differentiation, wound healing, and immune responses. The phosphorylation at Ser165 is particularly important for its activation and signaling, and this site is often targeted by antibodies for research applications such as Western blotting, immunohistochemistry, and immunofluorescence.