Non-phospho (Active) 尾-Catenin (Ser37/Thr41) refers to a form of the 尾-catenin protein that is not phosphorylated at the serine 37 and threonine 41 residues. This unphosphorylated state stabilizes 尾-catenin, allowing it to accumulate in the cytoplasm and subsequently translocate to the nucleus, where it acts as a transcriptional co-activator in the Wnt signaling pathway. The presence of non-phospho 尾-Catenin (Ser37/Thr41) is often associated with active Wnt signaling, which plays a critical role in cell proliferation, differentiation, and development. Detection of this form is commonly used in research to assess Wnt pathway activity.