CD195, also known as CCR5, is a G protein-coupled receptor that plays a critical role in immune responses and inflammation. It is expressed on immune cells such as T cells, monocytes, and macrophages, and binds chemokines like MIP-1α, MIP-1β, and RANTES to mediate leukocyte migration and recruitment to sites of inflammation. Additionally, CD195 is a co-receptor for HIV-1, facilitating viral entry into host cells, making it a key target in HIV research and treatment. Its involvement in various diseases, including HIV infection, cancer, and autoimmune disorders, highlights its significance in both immunology and clinical medicine.