Alexa Fluor® 647 Rat Anti-Mouse CD184 Antibody (S-R670),specification,price,image-Bio-Equip in China

Product Detail
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Product Specification

Host	Rat
Antigen	Mouse CD184
Synonyms	C-X-C chemokine receptor type 4; CXC-R4; CXCR-4; Fusin; Leukocyte-derived seven transmembrane domain receptor (LESTR); Pre-B-cell-derived chemokine receptor (PB-CKR); Stromal cell-derived factor 1 receptor (SDF-1 receptor); Cxcr4; Cmkar4; Lestr; Sdf1r
Location	Lysosome, Endosome, Cell membrane, Cell junction
Accession	P70658
Clone Number	S-R670
Antibody Type	Rat mAb
Isotype	IgG2b,k
Application	FCM
Reactivity	Ms
Positive Sample	C57BL/6 mouse thymocytes
Purification	Protein G
Concentration	0.05mg/ml
Conjugation	Alexa Fluor® 647
Physical Appearance	Liquid
Storage Buffer	PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300
Stability & Storage	12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.

Dilution

application	dilution	species
FCM	5μl per million cells in 100μl volume	Ms

Background

CD184, also known as CXCR4, is a CXC chemokine receptor encoded by the CXCR4 gene. It is a G protein-coupled receptor that specifically binds to stromal-derived factor-1 (SDF-1, also known as CXCL12), which is important for lymphocyte chemotaxis, hematopoietic stem cell homing, and quiescence. CXCR4 is also a co-receptor for HIV infection in CD4+ T cells, particularly for T-cell tropic HIV strains. Additionally, CXCR4 is involved in neuronal guidance during embryogenesis and adult life, and its dysregulation has been implicated in various diseases, including cancer and epilepsy.