IKKβ, also known as IκB kinase β or IKK2, is a key regulatory kinase responsible for the activation of NF-κB through phosphorylation at specific serine residues. It is a crucial component of the IKK complex, which includes IKKα, IKKβ, and the regulatory subunit IKKγ (NEMO). Dysregulation of IKKβ activity has been implicated in several cancer types, where it contributes to cancer cell survival, proliferation, invasion, angiogenesis, and metastasis. Targeting IKKβ has emerged as a promising strategy for cancer therapy, with several inhibitors being developed and some advancing to clinical trials.