Apo-D, or apolipoprotein D, is a glycoprotein with a molecular weight of approximately 33 kDa, primarily produced in the brain and testes rather than the liver, which is typical for most lipoproteins. It is a component of high-density lipoprotein (HDL) and plays a crucial role in lipid metabolism by interacting with lecithin-cholesterol acyltransferase, an enzyme involved in the metabolism of lipoproteins. Apo-D is also implicated in various neurological disorders and is considered a biomarker for conditions such as androgen insensitivity syndrome and certain neurodegenerative diseases. Its function in the nervous system is thought to be related to neuroprotection and repair, possibly due to its antioxidant and anti-inflammatory properties.