RBM15B, also known as RNA binding motif protein 15B, is a member of the SPEN (Split-end) family of proteins and is involved in various cellular processes. It functions as an RNA-binding protein that plays a key role in regulating N6-methyladenosine (m6A) methylation of RNAs, which affects mRNA splicing and processing. RBM15B is also implicated in the regulation of alternative splicing and acts as a cofactor for the nuclear export receptor NXF1, influencing mRNA export from the nucleus. Additionally, it has been associated with diseases such as Tatton-Brown-Rahman Syndrome and Wilms Tumor 1, highlighting its importance in both normal and pathological cellular functions.