SMARCD1, also known as BAF60A, is a protein that is part of the SWI/SNF family of chromatin remodeling complexes. It plays a crucial role in regulating gene transcription by altering chromatin structure, which involves the alteration of DNA-nucleosome topology in an ATP-dependent manner. SMARCD1 is involved in various biological processes, including neurogenesis and the regulation of lipid metabolism. It is also implicated in diseases such as Coffin-Siris Syndrome and has been identified as a prognostic marker in liver hepatocellular carcinoma. The protein is ubiquitously expressed in the nucleus of various tissues and is essential for the activation of specific gene signatures in multipotent progenitors.