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Home >Products> Reagents >Antibody> Lamin A/C Recombinant Rabbit mAb (Alexa Fluor® 647 Conjugate) (SDT-R041)
Lamin A/C Recombinant Rabbit mAb (Alexa Fluor® 647 Conjugate) (SDT-R041)
Lamin A/C Recombinant Rabbit mAb (Alexa Fluor® 647 Conjugate) (SDT-R041)
Origin of place Singapore
Model S0B1819-25μl
Supplier ANT BIO PTE.LTD.
Price 80
Hits 4
Updated 8/27/2025
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Product Specification


HostRabbit
AntigenLamin A/C
SynonymsPrelamin-A/C; 70 kDa lamin, Renal carcinoma antigen NY-REN-32; LMN1; LMNA
LocationNucleus
AccessionP02545
Clone NumberSDT-R041
Antibody TypeRecombinant mAb
IsotypeIgG
ApplicationICC, ICFCM
ReactivityHu
Positive SampleHeLa
PurificationProtein A
Concentration2 mg/ml
ConjugationAlexa Fluor® 647
Physical AppearanceLiquid
Storage Buffer

PBS, 25% Glycerol, 1% BSA, 0.3% Proclin 300

Stability & Storage12 months from date of receipt / reconstitution, 2 to 8 °C as supplied.

Dilution


applicationdilutionspecies
ICC1:2000Hu
ICFCM1:800Hu

Background

Lamin A/C is a crucial component of the nuclear lamina, a fibrous network that lines the inner nuclear membrane. Encoded by the LMNA gene, lamin A/C is an intermediate filament protein that plays a significant role in maintaining the structural integrity and mechanical stability of the nucleus. Beyond its structural function, lamin A/C is involved in a variety of cellular processes, including DNA replication, gene transcription regulation, and cell differentiation. It interacts with numerous proteins and genomic regions, influencing gene expression by modulating the accessibility of DNA to transcription factors. Mutations in the LMNA gene can lead to a group of diseases known as laminopathies, which include muscular dystrophy, dilated cardiomyopathy, and progeria, a premature aging syndrome. These mutations often disrupt the normal function of lamin A/C, causing cellular dysfunction and tissue-specific pathologies.

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