Product SpecificationHost | Rabbit | Antigen | Lamin A/C | Synonyms | Prelamin-A/C; 70 kDa lamin, Renal carcinoma antigen NY-REN-32; LMN1; LMNA | Location | Nucleus | Accession | P02545 | Clone Number | SDT-R041 | Antibody Type | Recombinant mAb | Isotype | IgG | Application | WB | Reactivity | Hu | Positive Sample | HeLa, HUVEC, HepG2 | Purification | Protein A | Concentration | 2 mg/ml | Conjugation | HRP | Physical Appearance | Liquid | Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 | Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied. |
Dilutionapplication | dilution | species | WB | 1:5000-1:10000 | Hu |
BackgroundLamin A/C is a crucial nuclear protein encoded by the LMNA gene, playing a significant role in maintaining the structural integrity of the cell nucleus. It is part of the nuclear lamina, a fibrous layer that provides support to the nuclear envelope and helps in organizing the chromatin. Beyond its structural function, lamin A/C is involved in various cellular processes, including gene regulation, DNA replication and repair, cell differentiation, and mechanosensing. Mutations in the lamin A/C gene can lead to a range of diseases collectively known as laminopathies, which include muscular dystrophy, lipodystrophy, and certain forms of cardiomyopathy. Additionally, lamin A/C has been implicated in cancer, where its deregulation can contribute to genomic instability and affect the mechanical resilience of tumor cells. bio-equip.cn
AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.
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