Product SpecificationHost | Rat | Antigen | Mouse CD186 | Synonyms | C-X-C chemokine receptor type 6; CXC-R6; CXCR-6; Cxcr6 | Location | Cell membrane | Accession | Q9EQ16 | Clone Number | S-R602 | Antibody Type | Rat mAb | Isotype | IgG2b,k | Application | FCM | Reactivity | Ms | Positive Sample | C57BL/6 mouse splenocytes | Purification | Protein G | Concentration | 2 mg/ml | Conjugation | Unconjugated | Physical Appearance | Liquid | Storage Buffer | PBS pH7.4 | Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied. |
Dilutionapplication | dilution | species | FCM | 1:200 | Ms |
BackgroundCD186, also known as CXCR6, is a G protein-coupled chemokine receptor with seven transmembrane domains. It is expressed on activated and memory T cells and its ligand is the chemokine CXCL16. CXCR6 plays a role in the recruitment of cells to inflamed sites and is also a coreceptor for HIV-1 and SIV to enter target cells, in conjunction with CD4. This receptor is involved in the regulation of T lymphocyte migration to various peripheral tissues and promotes cell-cell interaction with dendritic cells and fibroblastic reticular cells. Additionally, CXCR6/CCL16 controls the localization of resident memory T lymphocytes to different compartments of the lung and maintains airway resident memory T lymphocytes, which are crucial for defense against respiratory pathogens. bio-equip.cn
AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.
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