Histone H3 (acetyl K14), or H3K14ac, is a specific post-translational modification of the histone H3 protein at lysine 14, which plays a crucial role in chromatin structure and gene regulation. This acetylation event is particularly important for the silencing of ribosomal DNA (rDNA) and the aging process. H3K14 acetylation is also implicated in the regulation of replicative aging through its influence on replication-dependent nucleosome assembly. Moreover, H3K14ac has been shown to facilitate DNA repair within positioned nucleosomes by stabilizing the binding of the chromatin remodeler RSC (Remodels the Structure of Chromatin), thereby playing a significant role in the response to UV damage. This modification is generally associated with gene activation and is regulated by the balance of histone acetyltransferases (HATs) and histone deacetylases (HDACs), which add or remove acetyl groups from lysine residues on histone tails, respectively.