Phospho-NF-κB p65 (Ser468) refers to the phosphorylation of the p65 subunit of NF-κB at serine 468. This specific phosphorylation event plays a distinct role in the regulation of NF-κB signaling. Unlike many other phosphorylation sites on p65 that generally enhance its transcriptional activity, phosphorylation at Ser468 has been shown to inhibit p65's transactivation potential and can be involved in p65 ubiquitination and degradation, thereby reducing its transcriptional activity. This modification is part of the complex post-translational regulation of NF-κB, which is a critical mediator of cellular responses to various stimuli, including inflammation, immune responses, and cellular stress. The phosphorylation status of p65 at Ser468 can impact the cell's inflammatory response and may have implications for diseases where NF-κB signaling is dysregulated.