RFC2 protein, or replication factor C subunit 2, is a component of the replication factor C (RFC) complex, which is essential for DNA replication. RFC2, also known as A1 or RFC40, is involved in the elongation of primed DNA templates by DNA polymerase delta and epsilon, requiring the action of accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This protein plays a role in binding ATP and may contribute to promoting cell survival. Disruption of the RFC2 gene is associated with Williams syndrome, and it has been implicated in various cancers, suggesting its potential as a prognostic marker in diseases such as liver hepatocellular carcinoma and lung adenocarcinoma. The protein is mainly localized to the nucleoplasm and, in addition, to the Golgi apparatus, indicating its involvement in intracellular processes related to DNA replication and cell proliferation.