Histone H3 acetylation at lysine 36 (H3K36ac) is a post-translational modification that plays a crucial role in chromatin regulation. It is predominantly found at the promoters of actively transcribed genes and is associated with the regulation of transcription, as it can influence chromatin structure, promote the recruitment of transcriptional activators, and modulate the transition between active and repressive chromatin states. This modification is also implicated in processes such as splicing, nucleosome turnover, DNA repair, and the establishment of DNA methylation patterns, highlighting its importance in maintaining genomic stability and regulating gene expression.