SUZ12, also known as Zeste 12 Homolog, is a protein encoded by the human SUZ12 gene and is a component of the Polycomb Repressive Complex 2 (PRC2). SUZ12 plays a significant role in epigenetic modification, particularly in Regulating tyrosine trimethylation at position 27 of histone H3. SUZ12 has been implicated in the proliferation and metastasis of various types of cancer. It is overexpressed in tumors such as lung, stomach, colorectal, and breast cancer, where it promotes tumor growth and invasion. In hepatocellular carcinoma, SUZ12 downregulation has been associated with the upregulation of tumor stem cell marker genes, suggesting its importance in tumorigenesis and cancer progression.