TRIM30a, also known as the tripartite motif-containing protein 30 alpha, is a protein that plays a significant role in immune responses and cellular regulation. It has been found to make tumor cells more sensitive to natural killer (NK) cell-mediated immune surveillance. Overexpression of TRIM30a in tumor cells can slow down their growth in immunocompetent mice, but not in mice with depleted NK cells, indicating its role in enhancing the susceptibility of tumor cells to NK cell cytotoxicity. TRIM30a overexpression can impair the protein quality control (PQC) system in tumor cells by hindering the clearance of misfolded proteins and increasing the production of reactive oxygen species, suggesting that TRIM30a could be a potential tumor suppressor and immune modulator. TRIM30a acts as a negative-feedback regulator of the intracellular DNA and DNA virus-triggered response by targeting the stimulator of interferon genes (STING). It promotes the degradation of STING via K48-linked ubiquitination at Lys275, which is crucial for maintaining homeostasis and limiting the risk of autoimmunity.