Product Specification| Host | Rat | | Antigen | CD8α | | Synonyms | Lyt-2 | | Location | Cell membrane | | Accession | P01731 | | Clone Number | S-R540 | | Antibody Type | Rat mAb | | Isotype | Rat IgG2a,k | | Application | in vivo CD8+ T cell depletion | | Reactivity | Ms | | Purification | Protein G | | Concentration | 5 mg/ml | | Endotoxin | <2EU/mg | | Conjugation | Unconjugated | | Physical Appearance | Liquid | | Storage Buffer | PBS pH7.4, containing no preservative | | Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
BackgroundCD8α encodes the CD8 alpha chain of the αβT cells, proposed as a quantifiable indicator for CD8+ CTL recruitment or activity assessments and a robust biomarker for responses to anti-PD-1/PD-L1 therapy. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells. bio-equip.cn AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.
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