Product SpecificationHost | Rabbit | Antigen | nNOS | Synonyms | Nitric oxide synthase 1; Constitutive NOS; NC-NOS; NOS type I; Neuronal NOS (N-NOS; nNOS); Nitric oxide synthase, brain (bNOS); Peptidyl-cysteine S-nitrosylase NOS1 | Immunogen | Synthetic Peptide | Location | Cell membrane | Accession | P29475 | Clone Number | S-1641-70 | Antibody Type | Recombinant mAb | Isotype | IgG | Application | WB, IHC-P | Reactivity | Ms, Rt | Predicted Reactivity | Hu, Sh, Rb | Purification | Protein A | Concentration | 0.5 mg/ml | Conjugation | Unconjugated | Physical Appearance | Liquid | Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 | Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilutionapplication | dilution | species | WB | 1:1000 | Ms, Rt | IHC-P | 1:200 | Ms, Rt |
BackgroundNeuronally-derived Nitric Oxide Synthase (nNOS or NOS1) is a type of nitric oxide synthase enzyme. nNOS is mainly found in neurons and plays a crucial role in the central nervous system, particularly in synaptic signaling and plasticity. It is also present in skeletal muscle, where it regulates muscle contractility and local blood flow. nNOS interacts with a number of proteins, including post-synaptic density protein 95 (PSD-95), which is crucial for its localization at the postsynaptic density near the N-methyl-D-aspartate receptor (NMDAR). This interaction is important for coupling calcium influx through NMDA receptors to NO synthesis. nNOS has been implicated in various neuropathological states, including cognitive and motor deficits associated with early synaptic loss. It also negatively regulates neurogenesis under physiological and pathological conditions. bio-equip.cn
AntBio is a biotechnology group company dedicated to serving life sciences, aiming to help scientists accelerate research and improve work efficiency. AntBio provides comprehensive and high-quality reagent tools for basic research, drug development, and diagnosis, including research grade antibodies, proteins, biochemical reagents, and assay kits. These research tools are widely used in different segments of life science research. The group company currently consists of three brands, Absin, Starter-Bio and UA-Bio.
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