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nNOS Recombinant Rabbit mAb (S-1641-70)
nNOS Recombinant Rabbit mAb (S-1641-70)
Origin of place Singapore
Model S0B1106-25μl
Supplier ANT BIO PTE.LTD.
Price 100
Hits 1
Updated 8/27/2025
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Product Specification


HostRabbit
AntigennNOS
SynonymsNitric oxide synthase 1; Constitutive NOS; NC-NOS; NOS type I; Neuronal NOS (N-NOS; nNOS); Nitric oxide synthase, brain (bNOS); Peptidyl-cysteine S-nitrosylase NOS1
ImmunogenSynthetic Peptide
LocationCell membrane
AccessionP29475
Clone NumberS-1641-70
Antibody TypeRecombinant mAb
IsotypeIgG
ApplicationWB, IHC-P
ReactivityMs, Rt
Predicted ReactivityHu, Sh, Rb
PurificationProtein A
Concentration0.5 mg/ml
ConjugationUnconjugated
Physical AppearanceLiquid
Storage BufferPBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


applicationdilutionspecies
WB1:1000Ms, Rt
IHC-P1:200Ms, Rt

Background

Neuronally-derived Nitric Oxide Synthase (nNOS or NOS1) is a type of nitric oxide synthase enzyme. nNOS is mainly found in neurons and plays a crucial role in the central nervous system, particularly in synaptic signaling and plasticity. It is also present in skeletal muscle, where it regulates muscle contractility and local blood flow. nNOS interacts with a number of proteins, including post-synaptic density protein 95 (PSD-95), which is crucial for its localization at the postsynaptic density near the N-methyl-D-aspartate receptor (NMDAR). This interaction is important for coupling calcium influx through NMDA receptors to NO synthesis. nNOS has been implicated in various neuropathological states, including cognitive and motor deficits associated with early synaptic loss. It also negatively regulates neurogenesis under physiological and pathological conditions.

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